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Magnetization Transfer Imaging of Patients with Definite MS and Negative Conventional MRI Neurol 52:845-848, Filippi,M.,et al, 1999 See this aricle in Pubmed Article Abstract Our study examined acute MS lesions longitudinally by quantitative magnetization transfer (MT), an MRI technique that identifies tissue integrity and destruction. In 13 lesions, a marked decrease in the MTR was present early during the first 2 months after the onset of the lesion and was followed by a variable increase. In two other lesions, the MTR progressively declined. These results suggest that major early structural changes compatible with demyelination and followed by remyelination and gliosis or by continuous demyelination occur in new MS lesions. The various MTR profiles provide in vivo confirmation of the current knowledge of the progression in MS lesions. Furthermore, MTS may be used to monitor in vivo drug efficacy in new MS lesions.

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